Antibodies against vimentin (dako), î±-smooth muscle actin (î±-sma; dako), and s-100 protein (dako). The secondary antibodies used were goat serum against rabbit igg (kpl, gaithersburg, md, usa) and mouse igg (kpl). The epithelial cells of the small acinus part, the cyst part and the pavement part were positive for keratin (fig. 7), but those of the duct part were negative. The spindle-shaped cells surrounding the small acini were positive for vimentin and î±-sma. All the tumor cells were negative for s-100 protein and pituitary hormones. generic viagra View larger version: in this window in a new window download to powerpoint slide fig. 7. Intracranial tumor mass; cat no. 1. The tumor cells are positive for keratin. Immunostain counterstained with hematoxylin. Bar = 50 î¼m. Formalin-fixed tumor tissues were refixed in 2% glutal-dehyde and 1% osmium tetroxide, and embedded in epon 812. Ultrathin sections were double stained with 5% uranyl acetate and 5% lead nitrate, and observed using a jem 1200 electron microscope. Microvilli were sometimes observed at the free margin of flat cells lining the cyst. Tonofilaments in the cytoplasm and desmosome-like structures were also observed. low cost generic viagra The cells were bound to the basement membrane by hemidesmosome-like structures (fig. 8). Neoplastic cells in the other parts showed almost the same features. ordering viagra online View larger version: in this window in a new window download to powerpoint slide fig. discount online viagra 8. Intracranial tumor mass; cat no. 1. Electron microscopy of a tumor cell. Note the microvilli at the free margin (small arrows), tonofilaments in the cytoplasm (large arrow) and desmosome-like structures (large arrowheads). The cell binds to the basement membrane by hemidesmo-some-like structures (small arrowheads). Bar = 1. 2 î¼m. Case 2 was a 7-year-old, castrated male american short-hair cat, and was referred to an animal hospital because of mouth breathing and abnormal breathing sounds. Clinical signs did not improve in spite of medication with prednisolone, ofloxacin, antihistamine drugs and interferon. The cat was therefore referred to the vmc for a detailed examination. X-ray and endoscope examinations revealed a mass in the pharynx, which was removed by operation. buy discount viagra Histopathologic findings of the biopsy specimen were almost the same as in case 1. The tumor tissue was composed of small cuboidal anaplastic epithelial cells, often making ducts and small or large cysts (fig. overnight delivery generic viagra 9). The acinus pattern seen in case 1 was not observed. Immunohistochemical findings indicated that the ductular epithelial cells were positive for keratin and mesenchymal cells for both vimentin and î±-sma. Taking the tumor site into consideration, this tumor was diagnosed as craniopharyngioma. View larger version: in this window in a new window download to powerpoint slide fig. 9. Intracranial tumor mass; cat no. 2. The tumor tissue is composed of small cuboidal anaplastic epithelial cells, often making ducts and small or large cysts. He. Bar = hundred î¼m. Mri examination after the operation revealed that the tumor was located beneath the hypothalamus and extended to the right nasal cavity and bulla tympanica. Radiotherapy and removal of residual tumor were performed, but the tumor recurred repeatedly. Because the cat's general condition gradually worsened and blindness appeared, he was euthanatized according to the owner's wish. Autopsy was not permitted. Observation of the sample obtained at the last operation revealed invasion of the tumor cells into the skull bone, meninges, and neighboring peripheral nerves. On the basis of the clinical signs and histopathologic findings, this tumor was finally confirmed as malignant craniopharyngioma. Craniopharyngioma in humans is classified into ameloblastomatous type and papillomatous type. 1 in the former type, multiangular- or stellate-shaped tumor cells form focal or cord-like structures, and the nuclei of cells surrounding the structure are arranged as a palisade. ordering viagra online Many cysts are lined with thin epithelial cells, and keratinization can be seen. In the papillomatous type, squamous cells proliferate in papillary form. Electron microscopic findings of human cranio-pharyngioma have revealed that tumor cells and interstitial tissues are separated by the basement membrane, and that hemidesmosomes, desmosomes, and assembly of tonofilaments are present. 4 in the present two feline cases, the histopathologic findings were similar to those reported in previous canine 1 and murine 6, 9, 10 cases, in which solid proliferation of cuboidal, columnar, and squamous epithelial cells, and formation of cysts lined with the epithelial cells, were seen. In other reports, occasional keratinization and calcification were observed, but these were not present in the current cases. The immunohistochemical and electron microscopic findings, which supported the epithelial origin of the tumor, were also identical to those in other animals. 5, 9 the present feline cases were, therefore, diagnosed as craniopharyngioma. Pituitary adenoma/adenocarcinoma, chordoma, meningioma and granular cell tumor were considered as differential diagnoses of the present cases, but all were ruled out by morphologic differences. Pituitary adenoma/adenocarcinoma was denied because of negative immunohistochemical reaction to pituitary hormones. Chordoma usually consists of large-sized cells and massive intercellular matrices. Meningioma and granular cell tumor are characterized by a whirl-like arrangement of tumor cells and fine periodic acid schiff-positive cytoplasmic granules, respectively. The present feline cases were, in addition, diagnosed as malignant because of the severe anaplasia of the tumor cells and the invasion into the surrounding bones. Accordingly, the present cases were diagnosed as feline malignant craniopharyngioma. Though craniopharyngioma is not an extremely rare tumor in humans and dogs, only a few malignant cases hav. ordering viagra online ©2014  The Canadian Board for Respiratory Care Inc. / Le Conseil Canadien Des Soins Respiratoires Inc.

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